mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV.
Jin Young YangSanjar Batirovich MadrakhimovDong Hyuck AhnHun Soo ChangSang Joon JungSeung Kwan NahHa Yan ParkTae Kwann ParkPublished in: Cell communication and signaling : CCS (2019)
Our study suggests the mTOR as a critical player during CNV development in laser-induced mouse model through differentially acting with the mTORC1 and mTORC2. mTORC1 activity was high predominantly in inflammatory cells in CNV lesion, while mTORC2 activity was higher in vascular components and the RPE.