Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression.
Emmanuelle BornLarissa LipskaiaMarielle BreauAmal HoussainiDelphine Paulette BeaulieuElisabeth MarcosRémi PierreMarcio Do CruzeiroMarine LefevreGenevieve DerumeauxDmitry V BulavinMarion DelcroixRozenn QuarckVirinder ReenJesús GilDavid BernardJean-Michel FlamanSerge AdnotShariq AbidPublished in: Circulation (2022)
Elimination of senescent P-ECs by senolytic interventions may worsen pulmonary hemodynamics. These results invite consideration of the potential impact on pulmonary vessels of strategies aimed at controlling cell senescence in various contexts.
Keyphrases
- pulmonary hypertension
- pulmonary artery
- induced apoptosis
- pulmonary arterial hypertension
- cell cycle arrest
- single cell
- dna damage
- cell therapy
- physical activity
- endothelial cells
- endoplasmic reticulum stress
- signaling pathway
- cell death
- oxidative stress
- stress induced
- bone marrow
- pi k akt
- human health
- coronary artery