Methylated Polycyclic Polyprenylated Acylphloroglucinol Derivatives from Hypericum ascyron.
Jia-Wen HuMeng-Jiao ShiJia-Jia WangLi LiJian-Dong JiangTeng-Fei JiPublished in: Journal of natural products (2018)
Hyperascyrins A-H (1-11) and four known compounds (12-15) were acquired from the air-dried aerial parts of Hypericum ascyron and were all identified as methylated polycyclic polyprenylated acylphloroglucinol derivatives. Their structures were established by NMR spectroscopy, experimental and calculated electronic circular dichroism (ECD) data, and comparison with established compounds. Compounds 8 and 9 showed protection against paracetamol-induced HepG2 cell damage at 10 μM. The neuroprotective activities of all compounds (10 μM) were evaluated, and compounds 1 and 8 exhibited mild neuroprotection against glutamate-induced toxicity in SK-N-SH cells.
Keyphrases
- high glucose
- oxidative stress
- diabetic rats
- induced apoptosis
- stem cells
- high resolution
- electronic health record
- endothelial cells
- brain injury
- cerebral ischemia
- cell therapy
- cell death
- bone marrow
- big data
- signaling pathway
- deep learning
- machine learning
- endoplasmic reticulum stress
- cell proliferation
- subarachnoid hemorrhage
- anti inflammatory drugs