Remarkable response to pazopanib plus vivolumab in a patient with pericardial synovial sarcoma carrying a novel genotype BRCA2 c.968dupT: A case report.
Xing ZhangQinqin XuYong-Chang ZhangPublished in: Thoracic cancer (2024)
Pericardial synovial sarcomas (PSS) have a low incidence rate and are highly invasive with a dismal prognosis. Standard treatment includes surgery, radiotherapy and chemotherapy but with limited response. Here, we report the case of a 15-year-old nonsmoking youngster diagnosed with PSS who developed disease relapsed from surgery after 1 month. Next-generation sequencing (NGS) using baseline tissue was performed, and BRCA2 c.968dupT was detected. Then pazopanib (a multitargeted inhibitor) plus nivolumab (an immune checkpoint inhibitor) was administered, with a partial response and progression-free survival of 14 months. BRCA2 c.968dupT has not previously been reported in PSS and its response to targeted combination immunotherapy are not well characterized. Here, we report the efficacy of pazopanib combined with nivolumab in a PSS patient harboring BRCA2 c.968dupT and also provide the clinical evidence of the utility of NGS in exploring actionable mutations for solid tumor. Combination therapy based on immunotherapy may be a potential treatment choice for PSS harboring BRCA2 mutation.
Keyphrases
- combination therapy
- free survival
- minimally invasive
- breast cancer risk
- case report
- coronary artery bypass
- early stage
- acute myeloid leukemia
- surgical site infection
- acute lymphoblastic leukemia
- metastatic renal cell carcinoma
- diffuse large b cell lymphoma
- radiation therapy
- risk factors
- copy number
- coronary artery disease
- drug delivery
- radiation induced
- risk assessment
- climate change
- human health
- hodgkin lymphoma
- atrial fibrillation
- genome wide