Lynch Syndrome-Associated Variants and Cancer Rates in an Ancestrally Diverse Biobank.
Rachel E RosenblumCelina AngSabrina A SuckielEmily R SoperMeenakshi R SigireddiSinead CullinaGillian M BelbinAimee L LucasEimear E KennyNoura S Abul-HusnPublished in: JCO precision oncology (2020)
We found a higher prevalence of LS-associated variants among individuals of African ancestry in New York City. Although cancer risk is significantly increased among variant-positive individuals, the majority do not harbor a clinical diagnosis of LS, suggesting underrecognition of this disease.