Optimization of fermentation conditions for an Escherichia coli strain engineered using the response surface method to produce a novel therapeutic DNA vaccine for rheumatoid arthritis.
Juan LongXiao ZhaoFei LiangNan LiuYuying SunYongzhi XiPublished in: Journal of biological engineering (2018)
The present results provide a basis for further production of high-quality and high-yield therapeutic DNA vaccine pcDNA-CCOL2A1 in pilot-scale and even industrial-scale.
Keyphrases
- circulating tumor
- rheumatoid arthritis
- escherichia coli
- cell free
- single molecule
- heavy metals
- wastewater treatment
- study protocol
- nucleic acid
- disease activity
- circulating tumor cells
- pseudomonas aeruginosa
- cystic fibrosis
- interstitial lung disease
- systemic sclerosis
- klebsiella pneumoniae
- idiopathic pulmonary fibrosis