Overall Survival in Malignant Glioma Is Significantly Prolonged by Neurosurgical Delivery of Etoposide and Temozolomide from a Thermo-Responsive Biodegradable Paste.

Stuart James SmithBetty M TylerToby Gould Gareth J VealNoah GorelickJonathan RowlinsonRiccardo SerraAlison RitchiePhillip BerryAnnette OttoJohn ChoiNicolas SkuliMaria Estevez-CebreroKevin M ShakesheffHenry BremRichard G Grundy Ruman Rahman

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

The significant survival benefit of intracavity chemotherapy demonstrates clinical applicability of PLGA/PEG paste-mediated delivery of temozolomide and etoposide adjuvant to radiotherapy. PLGA/PEG paste offers a future platform for combination delivery of molecular targeted compounds.

Keyphrases

drug delivery
cancer therapy
early stage
drug release
locally advanced
molecularly imprinted
radiation therapy
newly diagnosed
squamous cell carcinoma
high throughput
free survival
rectal cancer
mass spectrometry
liquid chromatography