Exploring complement biomarkers in suspected axial spondyloarthritis.
Clara Mistegård JørgensenAnne TroldborgAnne Gitte LoftSteffen ThielLaura SpillerMikhail ProtopopovValeria Rios RodriguezBurkhard MucheJudith RademacherAnne-Katrin WeberSusanne LüdersJoachim SieperDenis PoddubnyyFabian ProftPublished in: RMD open (2024)
Serum levels of complement activation, that is, C3dg, and MASP-3 differed significantly between axSpA and cLBP patients after adjustment for CRP. Although combining HLA-B27 with measurements of L-ficolin, MASP-3 and C3dg increased the diagnostic specificity for axSpA, this seems unjustified due to the concomitant loss of sensitivity. However, both C3dg and MASP-3 were associated with axSpA diagnosis in multivariate logistic regression, suggesting an involvement of complement in the inflammatory processes and possibly pathogenesis in axSpA.