Chemo/radiotherapy-Induced Bone Marrow Niche Alterations.
Hassan RafieemehrMasumeh Maleki BehzadSaeed AzandehNiloofar FarshchiMohammad Ghasemi DehcheshmehNajmaldin SakiPublished in: Cancer investigation (2020)
Bone marrow (BM) niche is a specific microenvironment for hematopoietic stem cells (HSCs) as well as non-hematopoietic cells. Evidence shows that chemo/radiotherapy can lead to the disruption of different properties of HSCs such as proliferation, differentiation, localization, self-renewa, and steady-state of cell populations. Investigations have shown that the deregulation of balance within the marrow cavity due to chemo/radiotherapy could lead to bone loss, abnormal hematopoiesis, and enhanced differentiation potential of mesenchymal stem cells towards the adipogenic lineage. Therefore, understanding the underlying mechanisms of chemo/radiotherapy induced BM niche changes may lead to the application of appropriate therapeutic agents to prevent BM niche defects. Highlights Chemo/radiotherapy disrupts the steady-state of bone marrow niche cells and result in deregulation of normal balance of stromal cell populations. Chemo/radiotherapy agents play a significant role in reducing of bone formation as well as fat accumulation in the bone marrow niche. Targeting molecular pathways may lead to recovery of bone marrow niches after chemo/radiotherapy.
Keyphrases
- bone marrow
- locally advanced
- mesenchymal stem cells
- early stage
- rectal cancer
- photodynamic therapy
- radiation therapy
- squamous cell carcinoma
- stem cells
- cancer therapy
- radiation induced
- induced apoptosis
- combination therapy
- umbilical cord
- cell therapy
- single cell
- adipose tissue
- signaling pathway
- bone loss
- high glucose
- risk assessment
- endothelial cells
- drug delivery
- single molecule
- genetic diversity
- stress induced