Dose-escalated accelerated hypofractionation for elderly or frail patients with a newly diagnosed glioblastoma.

Haley K PerlowAlexander YaneyMichael YangBrett KlamerJennifer MatsuiRaju R RavalDukagjin M BlakajAndrea ArnettSasha BeyerJames B ElderMario AmmiratiRussell LonserDouglas HardestyShirley OngPierre GiglioClement PillainayagamJustin GoranovichJohn GreculaArnab ChakravartiVinai GondiPaul D BrownJoshua David Palmer

Published in: Journal of neuro-oncology (2022)

Isoeffective dosing to 52.5 Gy in 15 fractions was associated with superior OS compared to standard of care 40 Gy in 15 fractions. These hypothesis generating data support accelerated hypofractionation in future prospective trials.

Keyphrases

newly diagnosed
community dwelling
healthcare
palliative care
electronic health record
middle aged
current status
quality improvement
big data
pain management
affordable care act
machine learning
data analysis
health insurance