Nuclear and Mitochondrial Genome, Epigenome and Gut Microbiome: Emerging Molecular Biomarkers for Parkinson's Disease.
Gleyce F CabralAna Paula SchaanGiovanna Chaves CavalcanteCamille Sena-Dos-SantosTatiane Piedade de SouzaNatacha M Souza Port'sJhully Azevedo Dos Santos PinheiroÂndrea Kely Campos Ribeiro Dos SantosAmanda Ferreira VidalPublished in: International journal of molecular sciences (2021)
Genomic variation, regulation by epigenomic mechanisms, as well as the influence of the host gut microbiome seem to have a crucial role in the onset and progress of PD, thus are considered potential biomarkers. As such, the human nuclear and mitochondrial genome, epigenome, and the host gut microbiome might be the key elements to the rise of personalized medicine for PD patients.