MMP1, IL-1β, sTNFR-1, and IL-6 are prognostic factors for patients with unresectable or metastatic renal cell carcinoma treated with immune checkpoint inhibitors.
Hirotaka NagasakaTakeshi KishidaTaku KouroYuka IgarashiShinichi TakebeShotaro YamamotoTakuya KondoMitsuyuki KoizumiHideyuki TeraoTakahisa SuzukiNoboru NakaigawaHidetomo HimuroFeifei WeiTetsuro SasadaPublished in: International journal of clinical oncology (2024)
MMP1 may be associated with severe irAE, and MMP1, IL-1β, sTNFR-1, and IL-6 could serve as prognostic factors in unresectable or metastatic RCC treated with ICIs. MMP1 and IL-6 were independent predictors of PFS and OS, respectively. Thus, inhibiting these soluble factors may be promising for enhancing antitumor responses in patients with RCC treated with ICIs.