[Quantitative susceptibility mapping in assessment of inflammation and neurodegeneration in multiple sclerosis].
M S MatrosovaV V BryukhovG N BelskayaMarina V KrotenkovaPublished in: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2022)
Quantitative susceptibility mapping (QSM) is a relatively new MRI technique that may potentially help estimate iron concentrations in the brain. It plays a big role in diagnosis of many pathological processes, including multiple sclerosis (MS). Iron metabolism in the brain is a complex and not fully understood process. It is known that the content of iron in the brain increases with age; in addition, its accumulation is often observed in many neurodegenerative diseases, including MS foci, and its amount changes over time. In this regard, the values of magnetic susceptibility obtained using QSM can potentially become a convenient biomarker that reflects the latent activity and progression of MS, which, in turn, can influence the choice of therapy and the tactics of treating patients.
Keyphrases
- multiple sclerosis
- white matter
- high resolution
- resting state
- mass spectrometry
- ms ms
- end stage renal disease
- functional connectivity
- iron deficiency
- newly diagnosed
- oxidative stress
- magnetic resonance imaging
- magnetic resonance
- chronic kidney disease
- high density
- big data
- cerebral ischemia
- machine learning
- peritoneal dialysis
- mesenchymal stem cells
- deep learning
- artificial intelligence
- molecularly imprinted
- liquid chromatography
- patient reported