Young-onset gastric cancer and Epstein-Barr Virus (EBV) - a major player in the pathogenesis?
Assaf MooreElad HikriTal Goshen-LagoTamar BarkanSara MorgensternElena BrookAnnett MadererWilfried RothNoa GordonHanoch KashtanBaruch BrennerMarkus MoehlerIrit Ben AharonPublished in: BMC cancer (2020)
Our study indicates that EBV subtype is more prevalent in young-onset GC and may play a key role in the pathogenesis. Higher rate of PD-L1 positivity in young-onset GC could change treatment strategies. We are currently evaluating these findings in a prospective trial.