FOSL2-mediated transcription of ISG20 induces M2 polarization of macrophages and enhances tumorigenic ability of glioblastoma cells.

Hailong DuJianping SunXiaoliang WangLei ZhaoXiaosong LiuChao ZhangFeng WangJianliang Wu

Published in: Journal of neuro-oncology (2024)

This study demonstrates that FOSL2 is highly expressed in GBM due to DNA hypomethylation. It activates transcription of ISG20, thus promoting M2 polarization of macrophages and GBM development.

Keyphrases

induced apoptosis
transcription factor
cell cycle arrest
circulating tumor
cell free
cell death
cell proliferation
nucleic acid