PLCβ2 Promotes VEGF-Induced Vascular Permeability.

Kathryn N PhoenixZhichao YueLixia YueChunxia G CroninBruce T LiangLuke H Hoeppner Kevin P Claffey

Published in: Arteriosclerosis, thrombosis, and vascular biology (2022)

The results implicate PLCβ2 as a key positive regulator of VEGF-induced vascular permeability through regulation of both calcium flux and phosphatidylinositol 4,5-bisphosphate levels at the cellular level. Targeting of PLCβ2 in a therapeutic setting may provide a novel approach to regulating vascular permeability in patients.

Keyphrases

endothelial cells
high glucose
end stage renal disease
diabetic rats
vascular endothelial growth factor
chronic kidney disease
newly diagnosed
prognostic factors
patient reported outcomes