Computer-aided design of PVR mutants with enhanced binding affinity to TIGIT.
Xiaowen ZhouJiangfeng DuXiuman ZhouXiaoshuang NiuWanqiong LiChunxia ChenSifan LvAijun WuShanshan GouYixuan SunWenjie ZhaiLu QiuYuanming QiWenshan ZhaoYan-Feng GaoPublished in: Cell communication and signaling : CCS (2021)
The MD simulations analysis provided new insights into the TIGIT/PVR interaction model, and the identified PVR mutants (PVRS72W, PVRS72R, PVRG131V and PVRS132Q) could serve as new candidates for immunotherapy to block TIGIT/PVR. Video Abstract.