Measurable residual disease study through three different methods can anticipate relapse and guide early interventions in childhood acute lymphoblastic leukemia.
Eduardo Ramos ElbalJose Luis FusterJosé A CampilloAna María GaleraMar Bermúdez CortésMaría Esther LlinaresIrene JiménezMercedes PlazaHelios Martínez BanaclochaJosé Antonio GaliánMiguel Blanquer BlanquerMaría Victoria Martínez SánchezManuel MuroAlfredo MinguelaPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2023)
MFC, FISH and RT-PCR are complementary methods for MRD monitoring in pediatric ALL. Although, our data clearly show that MDR positive detection is associated with relapse, continuation of standard treatment, intensification or other early interventions were able to halt relapse in patients with different risks and genetic background. More sensitive and specific methods are warranted to enhance this approach. However, whether early treatment of MRD can improve overall survival in patients with childhood ALL needs to be evaluated in adequately controlled clinical trials.