Post-transplant-cyclophosphamide and short-term Everolimus as graft-versus-host-prophylaxis in patients with relapsed/refractory lymphoma and myeloma-Final results of the phase II OCTET-EVER trial.
Tim RichardsonChristof ScheidMarco HerlingLukas P FrenzelCarmen HerlingMarta Rebecca Cruz AguilarSebastian TheurichMichael HallekUdo HoltickPublished in: European journal of haematology (2024)
Using PTCy and short-term Everolimus is safe with low rates of aGvHD and no severe aGvHD or cGvHD translating into a low rate of non-relapse mortality. Our results in this difficult to treat patient population are encouraging and warrant further studies.
Keyphrases
- phase ii
- clinical trial
- open label
- diffuse large b cell lymphoma
- phase iii
- multiple myeloma
- acute myeloid leukemia
- acute lymphoblastic leukemia
- placebo controlled
- double blind
- cardiovascular events
- study protocol
- risk factors
- case report
- cardiovascular disease
- early onset
- hodgkin lymphoma
- type diabetes
- newly diagnosed
- case control