Global treatment rate and barriers to DAA therapy: A systematic review and meta-analysis of 146 studies and 1,760,352 HCV patients.
Vy H NguyenDaniel Q HuangMichael H LeMichelle JinEunice Yewon LeeLinda HenrySanjna Nilesh NerurkarEiichi OgawaKhin Naing ThinMargaret L P TengKang Shiong GohJustin Chua Ying KaiConnie WongDarren J H TanLe Thi Thanh ThuyHoang HaiMasaru EnomotoRamsey C CheungMindie H NguyenPublished in: Liver international : official journal of the International Association for the Study of the Liver (2023)
Though a marked improvement from IFN/DAA, the treatment rate with IFN-free DAA remains suboptimal (52.3% overall, 32.3% in HCC patients). Non-adherence to clinical follow-up and lack of disease awareness were treatment barriers.