Engagement of Foxh1 in chromatin regulation revealed by protein interactome analyses.
Jeff Jiajing ZhouPaula Duyen PhamHan HanWenqi WangKen W Y ChoPublished in: Development, growth & differentiation (2022)
Early embryonic cell fates are specified through coordinated integration of transcription factor activities and epigenetic states of the genome. Foxh1 is a key maternal transcription factor controlling the mesendodermal gene regulatory program. Proteomic interactome analyses using FOXH1 as a bait in mouse embryonic stem cells revealed that FOXH1 interacts with PRC2 subunits and HDAC1. Foxh1 physically interacts with Hdac1, and confers transcriptional repression of mesendodermal genes in Xenopus ectoderm. Our findings reveal a central role of Foxh1 in coordinating the chromatin states of the Xenopus embryonic genome.
Keyphrases
- transcription factor
- genome wide
- gene expression
- dna methylation
- genome wide identification
- embryonic stem cells
- single cell
- dna binding
- binding protein
- dna damage
- cell therapy
- social media
- cell free
- histone deacetylase
- stem cells
- pregnant women
- physical activity
- birth weight
- mesenchymal stem cells
- weight loss
- small molecule
- pregnancy outcomes
- heat shock