Lorazepam Stimulates IL6 Production and Is Associated with Poor Survival Outcomes in Pancreatic Cancer.

Abigail C Cornwell Arwen A Tisdale Swati Venkat Kathryn E Maraszek Abdulrahman A Alahmari Anthony George Kristopher M Attwood Madison George Donald Rempinski Janusz Franco-Barraza Mukund Seshadri Mark D Parker Eduardo Cortes Gomez Christos Fountzilas Edna Cukierman Nina G Steele Michael E Feigin

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

We demonstrate that LOR stimulates fibrosis and inflammatory signaling, promotes desmoplasia and ischemic necrosis, and is associated with decreased pancreatic cancer patient survival.

Keyphrases

case report
oxidative stress
ischemia reperfusion injury
free survival
cerebral ischemia
brain injury