A Preclinical Trial and Molecularly Annotated Patient Cohort Identify Predictive Biomarkers in Homologous Recombination-deficient Pancreatic Cancer.

Yifan WangJin Yong Patrick ParkAlain PacisRobert E DenrocheGun Ho JangAmy ZhangAdeline CuggiaCeline DomecqJean MonlongMaria Raitses-GurevichRobert C GrantAyelet BorgidaSpring HolterChani StosselSimeng BuMehdi MasoomianIllinca M Lungu Timothy J Whelan Julie M Wilson Zu-Hua GaoYasser RiazalhosseiniJamil AsselahNathaniel BouganimTatiana CabreraLouis-Martin BoucherDavid ValentiJames BiagiCelia M T GreenwoodPaz PolakWilliam D FoulkesTalia GolanGrainne M O'KaneSandra E FischerJennifer J KnoxSteven GallingerGeorge Zogopoulos

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

In summary, we propose a predictive and prognostic model of gBRCA-mutated PDAC on the basis of HRD genomic hallmarks, Ki67 index, tumor ploidy, and transcriptomic subtype.

Keyphrases

dna repair
dna damage
case report
clinical trial
study protocol
phase iii
single cell
phase ii
wild type
copy number
rna seq
neoadjuvant chemotherapy
stem cells
cell therapy
squamous cell carcinoma
radiation therapy
mesenchymal stem cells
open label