Impact of hepatocellular carcinoma aetiology and liver function on the benefit of surveillance: A novel approach for the adjustment of lead-time bias.
Hidenori ToyodaTakashi KumadaToshifumi TadaKazuyuki MizunoAtsushi HiraokaKunihiko TsujiToru IshikawaTomoyuki AkitaJunko TanakaPublished in: Liver international : official journal of the International Association for the Study of the Liver (2018)
The survival benefit of surveillance for patients with HCC was demonstrated after adjustment for lead-time bias with novel, more accurate methodology. However, the benefits differed based on liver function and may vary largely by patients because of wide variation in TVDT.