Association of cytochromes P450 3A422 and 3A53 genotypes and polymorphism with response to simvastatin in hypercholesterolemia patients.

Elbatool G ElalemMusharraf JelaniAlaa KhedrAftab AhmadTareef Y AlaamaMohamed Nabeel AlaamaHuda Mohammed Alkreathy Zoheir A Damanhouri

Published in: PloS one (2022)

The present study showed associations between CYP3A4*22 (rs35599367) and CYP3A5*3 (rs776746) SNP combination genotypes with response to statins in hypercholesterolemia. Patients who had either a mutant homozygous allele for CYP3A5*3 or mutant homozygous and heterozygous alleles for CYP3A4*22 showed increased response to lower TC and LDL-C levels.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
cardiovascular disease
cardiovascular events
prognostic factors
low density lipoprotein
genome wide
gene expression
patient reported outcomes
coronary artery disease
high density