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Sulphur ylide-mediated cyclopropanation and subsequent spirocyclopropane rearrangement reactions.

Qing-Song DaiJun-Long LiQi-Wei WangSi-Lin YangYing-Mao TaoMei-Hao HeQing-Zhu LiBo HanXiang Zhang
Published in: Organic & biomolecular chemistry (2022)
The efficient construction of cyclopropyl spiroindoline skeletons and the exploration of related follow-up synthetic transformations have elicited considerable interest amongst members of the chemistry community. Here, we describe a formal (2 + 1) annulation and three-component (1 + 1 + 1) cascade cyclisation via sulphur ylide cyclopropanation under mild conditions. The spiro-cyclopropyl iminoindoline moiety can be readily transformed into another medicinally interesting pyrrolo[3,4- c ]quinoline framework through a novel rearrangement process.
Keyphrases
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