BRAF V600E immunohistochemistry can reliably substitute BRAF molecular testing in the Lynch syndrome screening algorithm in colorectal cancer.

Federica GrilloMichele PaudiceSimona PigozziMaria DonoSonia LastraioliMarialuisa LugaresiSilvia BozzanoCamilla TognoniMurad AliStefania ScialleroAlberto PucciniAngelo Paolo Dei TosLuca Mastracci

Published in: Histopathology (2024)

IHC can be used as a reliable surrogate of molecular testing after stringent in-house validation.

Keyphrases

machine learning
metastatic colorectal cancer
single molecule
wild type
neural network