European polygenic risk score for prediction of breast cancer shows similar performance in Asian women.
Weang Kee HoMin-Min TanNasim MavaddatMei-Chee TaiShivaani MariapunJingmei LiPeh-Joo HoJoe G DennisJonathan P TyrerManjeet K BollaKyriaki MichailidouQin WangDaehee KangJi-Yeob ChoiSuniza JamarisXiao-Ou ShuSook-Yee YoonSue-Kyung ParkSung-Won KimChen-Yang ShenJyh-Cherng YuErn Yu TanPatrick Mun Yew ChanKenneth Ross MuirArtitaya LophatananonAnna H WuDaniel O StramKeitaro MatsuoHidemi ItoChing Wan ChanJoanne NgeowWei Sean YongSwee Ho LimGeok Hoon LimAva KwongTsun L ChanSu Ming TanJaime SeahEsther M JohnAllison W KurianWoon-Puay KohChiea Chuen KhorMotoki IwasakiTaiki YamajiKiak Mien Veronique TanKiat Tee Benita TanJohn J SpinelliKristan J AronsonSiti Norhidayu HasanKartini RahmatAnushya VijayananthanXueling S SimPaul David Peter PharoahWei ZhengAlison M DunningJacques SimardRob Martinus van DamCheng-Har YipNur Aishah Mohd TaibMikael HartmanDouglas F EastonSoo-Hwang TeoAntonis C AntoniouPublished in: Nature communications (2020)
Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a ~2.7-fold risk and women in the lowest 1% of PRS distribution has ~0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.