HGF alleviates septic endothelial injury by inhibiting pyroptosis via the mTOR signalling pathway.

Fei PengWei ChangQin SunXinyi XuJianfeng XieHaibo QiuHaibo Qiu

Published in: Respiratory research (2020)

These results demonstrated that HGF protected mitochondrial physiology by activating mTOR signalling to partially ameliorate endothelial pyroptosis and attenuate vascular endothelial injury and acute lung injury in sepsis animal model.

Keyphrases

endothelial cells
acute kidney injury
signaling pathway
nlrp inflammasome
cell proliferation
intensive care unit
oxidative stress
lipopolysaccharide induced
lps induced
inflammatory response
septic shock
mouse model