Effect of Fibrosis Regionality on Atrial Fibrillation Recurrence: Insights from DECAAF II.
Ala' AssafMario MekhaelCharbel NoujaimNour ChoumanHadi YounesHan FengAbdel-Hadi El HajjarBotao ShanPeter M KistlerOmar KreidiehNassir F MarroucheEoin DonnellanPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2023)
We have confirmed that atrial cardiomyopathy and remodeling is not a homogenous process, with variations in different regions of the LA. Atrial fibrosis does not uniformly affect the LA, and the left PV antral region has more fibrosis than the rest of the wall. Furthermore, we identified regional fibrosis of the LAA as a significant predictor of AF recurrence post-ablation in patients receiving MRI-guided fibrosis ablation in addition to standard PVI.