MHTP, a synthetic tetratetrahydroisoquinoline alkaloid, attenuates lipopolysaccharide-induced acute lung injury via p38MAPK/p65NF-κB signaling pathway-TLR4 dependent.
Bianka Márcia do Nascimento XavierLarissa Adilis Maria Paiva FerreiraLaércia Karla Diega Paiva FerreiraFrancisco Allysson Assis Ferreira GadelhaTalissa Mozzini MonteiroLuiz André de Araújo SilvaLuís Cesar RodriguesMarcia Regina PiuvezamPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2019)
These data showed for the first time the beneficial and effective activity of a nasal treatment with a synthetic tetrahydroisoquinoline alkaloid on an experimental model of ALI and pointed out the molecular mechanism related to it.
Keyphrases
- lipopolysaccharide induced
- inflammatory response
- signaling pathway
- lps induced
- pi k akt
- toll like receptor
- electronic health record
- nuclear factor
- epithelial mesenchymal transition
- oxidative stress
- immune response
- big data
- induced apoptosis
- combination therapy
- machine learning
- artificial intelligence
- cell proliferation
- chronic rhinosinusitis
- deep learning