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β-AlkenylBODIPY Dyes: Regioselective Synthesis via Oxidative C-H Olefination, Photophysical Properties, and Bioimaging Studies.

Jun WangYongxin LiQingbao GongHua WangErhong HaoPui-Chi LoLijuan Jiao
Published in: The Journal of organic chemistry (2019)
A series of 2-alkenyl- and 2,6-dialkenylboron dipyrromethene (BODIPY) derivatives were synthesized through Pd(II)-catalyzed regioselective and stereoselective oxidative C-H olefination in one step. The 2-alkenyl BODIPY derivative further reacted with various amines regioselectively at the 5-position through direct oxidative nucleophilic substitution. The photophysical properties of the 2-alkenyl- and 2,6-dialkenyl-substituted BODIPYs were investigated, which showed great potential in fluorescent bioimaging.
Keyphrases
  • living cells
  • fluorescent probe
  • quantum dots
  • single molecule
  • molecular docking
  • atomic force microscopy
  • room temperature
  • human health
  • high resolution
  • climate change
  • aqueous solution
  • ionic liquid