Physicochemical Evaluation and Pharmacological Screening of Fernando Adenophylla Steenis Fruits.
Arham HassanMuhammad Asad SaeedMuhammad ZamanNazia AslamMahtab Ahmad KhanAzmat Ali KhanAmer M AlanaziMilton Kumar KunduHasi Rani BaraiAthanasios AlexiouMarios PapadakisPublished in: Chemistry & biodiversity (2024)
The current study aimed to evaluate the physicochemical properties of Fernandoa adenophylla. Powder studies were carried out to estimate the quantitative physicochemical characteristics of the crude drug, including moisture content, ash content, and extractive values. Using a Soxhlet apparatus and different analytical grade solvents, 3 sample extracts of a crude drug were made. To evaluate the potentially toxic nature, an acute oral toxicity study was performed as per OECD guideline no. 423. Sample extracts were tested and analyzed by ANOVA for pharmacological potential (analgesic, antipyretic, and antidiabetic) using Wister-Albino rats. Where physicochemical analysis indicated purity, quality, and presence of organic/inorganic materials in crude drug extracts, no sign of mortality was found up to 2000 mg/kg of body weight of Fernandoa adenophyllas extracts. Analgesic activity was observed in all sample extracts, whereas only chloroform and ethanolic extracts expressed antipyretic and antidiabetic potential. Ethanolic extract was found to be most potent in pharmacological potential as 200 mg/kg extract dose exhibited %age pain inhibition of 55.12 % and reduced body temperature from 39.78±0.03 °C to 37.22±0.02 °C in hyperthermic rats. A decrease in blood glucose levels up to 57.88 % was observed on the 21 st day of the treatment with 500 mg/kg ethanolic extract.
Keyphrases
- blood glucose
- anti inflammatory
- body weight
- oxidative stress
- neuropathic pain
- chronic pain
- liver failure
- drug induced
- cardiovascular disease
- emergency department
- adverse drug
- pain management
- metabolic syndrome
- intensive care unit
- mass spectrometry
- liquid chromatography
- respiratory failure
- heavy metals
- smoking cessation
- mechanical ventilation
- aortic dissection
- postoperative pain