Evaluation of VTP-50469, a menin-MLL1 inhibitor, against Ewing sarcoma xenograft models by the pediatric preclinical testing consortium.

Raushan T KurmashevaAbhik BandyopadhyayEdward FavoursVanessa Del PozoSamson GhiluDoris A PhelpsGerard M McGeehanStephen W EricksonMalcolm A SmithPeter J Houghton

Published in: Pediatric blood & cancer (2020)

In contrast to its high level of activity against MLL1-rearranged leukemia xenografts, VTP-50469 shows little activity against EwS models.

Keyphrases

acute myeloid leukemia
magnetic resonance
bone marrow
protein protein
stem cells
magnetic resonance imaging
cell therapy
contrast enhanced
computed tomography
small molecule
mesenchymal stem cells