Effect of intermittent subchronic MK-801 administration on dopamine synthesis capacity and responsiveness in the prefrontal cortex.

Kazuro ShibataKosuke EnomotoTakahiro TsutsumiHiroyuki MuraokaTatsu FuwaMasahiko KawanoJun IshigookaKen Inada Katsuji Nishimura Hidehiro Oshibuchi

Published in: Neuropsychopharmacology reports (2024)

These findings offer crucial biochemical insights into the diverse impacts of NMDAR antagonists on dopamine dynamics and the distinct therapeutic mechanisms associated with ketamine in depression treatment. However, further investigation is imperative to pinpoint potential inconsistencies stemming from variances in drug type, dosage, or administration frequency.

Keyphrases

prefrontal cortex
uric acid
depressive symptoms
emergency department
sleep quality
risk assessment
adverse drug
combination therapy
chronic pain
replacement therapy