Rapid screening of COVID-19 patients using white blood cell scattergrams, a study on 381 patients.
Jennifer OsmanJérome LambertMarie TempléFloriane DevauxRémy FavreClaire FlaujacDelphine BridouxStéphanie Marque-JuilletFabrice BruneelFrançois MignonErnesto Diaz-FloresVéronique HentgenAlix Greder-BelanReza AzarianMehrsa KoukabiPhilippe RousselotVictoria RaggueneauBenjamin ManéglierPublished in: British journal of haematology (2020)
Complementary tools are warranted to increase the sensitivity of the initial testing for COVID-19. We identified a specific 'sandglass' aspect on the white blood cell scattergram of COVID-19 patients reflecting the presence of circulating plasmacytoid lymphocytes. Patients were dichotomized as COVID-19-positive or -negative based on reverse transcriptase polymerase chain reaction (RT-PCR) and chest computed tomography (CT) scan results. Sensitivity and specificity of the 'sandglass' aspect were 85·9% and 83·5% respectively. The positive predictive value was 94·3%. Our findings provide a non-invasive and simple tool to quickly categorize symptomatic patients as either COVID-19-probable or -improbable especially when RT-PCR and/or chest CT are not rapidly available.
Keyphrases
- computed tomography
- end stage renal disease
- sars cov
- coronavirus disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- magnetic resonance imaging
- stem cells
- positron emission tomography
- contrast enhanced
- dual energy
- magnetic resonance
- image quality
- mesenchymal stem cells
- respiratory syndrome coronavirus