Effect of alcohol on chronic pelvic pain and prostatic inflammation in a mouse model of experimental autoimmune prostatitis.

Li-Gang ZhangJing ChenJia-Lin MengYong ZhangYi LiuChang-Sheng ZhanXian-Guo ChenLi ZhangChao-Zhao Liang

Published in: The Prostate (2019)

This study indicated that alcohol could aggravate the severity of prostatic inflammation in EAP model though activating the NLRP3 inflammasome. Furthermore, the role of MCC950 in inhibiting NLRP3 inflammasome and decreasing IL-1β secretion to alleviate EAP severity may show that it is a promising therapeutic agent for CP/CPPS.

Keyphrases

nlrp inflammasome
mouse model
oxidative stress
signaling pathway
benign prostatic hyperplasia
chronic pain
radical prostatectomy
alcohol consumption
multiple sclerosis
neuropathic pain
prostate cancer
pain management
drug induced
spinal cord injury
spinal cord