Probing stress induced phase transformation in aspirin polymorphs using Raman spectroscopy enabled nanoindentation.
Praveena ManimundaS A Syed AsifManish Kumar MishraPublished in: Chemical communications (Cambridge, England) (2019)
Nanoindentation has extensively been used to measure the mechanical properties of molecular crystals. However, the possibilities of stress induced polymorphic transformation during indentation are still unexplored. Here, we have adopted a spatially synchronized Raman spectroscopy and nanoindentation technique to probe indentation induced polymorphic transformation in aspirin polymorphs. Spatial hardness maps, generated using an accelerated property mapping technique, showed micro-domain formation in aspirin form II crystals.
Keyphrases
- stress induced
- raman spectroscopy
- low dose
- cardiovascular events
- antiplatelet therapy
- room temperature
- single molecule
- atomic force microscopy
- multidrug resistant
- high resolution
- high glucose
- anti inflammatory drugs
- acute coronary syndrome
- living cells
- diabetic rats
- molecular dynamics simulations
- percutaneous coronary intervention
- quantum dots
- drug induced
- atrial fibrillation
- high density
- fluorescent probe