Vanillic Acid Ameliorates Demyelination in a Cuprizone-Induced Multiple Sclerosis Rat Model: Possible Underlying Mechanisms.

Sally M SafwatMahmoud El TohamyMoutasem Salih AboonqAmaal AlrehailiAhmad A Assinnari Abdulrahman S BahashwanAhmed A ElGendyAbdelaziz M Hussein

Published in: Brain sciences (2023)

The current study demonstrated a neuroprotective effect for VA against the Cup-induced demyelinating rat model. This effect might be precipitated by the inhibition of inflammation, oxidative stress, and apoptosis.

Keyphrases

oxidative stress
diabetic rats
multiple sclerosis
high glucose
dna damage
ischemia reperfusion injury
drug induced
cell death
mouse model
cell proliferation
cell cycle arrest
brain injury
signaling pathway
cerebral ischemia
stress induced