Health-Related Quality of Life in Children and Adolescents with Congenital Adrenal Hyperplasia: A Systematic Review and Meta-Analysis.

Based on available data, children/adolescents with CAH had preserved physical QoL but impaired psychosocial QoL, especially in the school domain. Factors associated with lower QoL included poor disease-control, and disease/treatment-related complications. There is a need for further high-quality research that investigates the relationship between disease-control, provision of psychosocial support and improvement in QoL in children/adolescents with CAH.