Tamoxifen activity against Plasmodium in vitro and in mice.
Ada WeinstockJulio Gallego-DelgadoCláudia GomesJulian ShermanCyrus NikainSandra GonzalezEdward FisherAna RodriguezPublished in: Malaria journal (2019)
Tamoxifen and its active metabolite, 4-hydroxytamoxifen, have significant activity against the human parasite P. falciparum in vitro and the rodent parasite P. berghei in vivo. This activity may be useful for prevention of malaria in patients taking this drug chronically, but also represents a major problem for scientists using the conditional mutagenic Cre/LoxP system in the setting of rodent malaria. Allowing mice to clear tamoxifen before starting a Plasmodium infection allows the use the Cre/LoxP conditional mutagenic system to investigate gene function in specific tissues.
Keyphrases
- plasmodium falciparum
- breast cancer cells
- end stage renal disease
- positive breast cancer
- endothelial cells
- high fat diet induced
- newly diagnosed
- ejection fraction
- gene expression
- emergency department
- genome wide
- toxoplasma gondii
- type diabetes
- prognostic factors
- patient reported outcomes
- copy number
- trypanosoma cruzi
- wild type
- insulin resistance
- adipose tissue
- patient reported