Host genetics but not commensal microbiota determines the initial development of systemic autoimmune disease in BXD2 mice.

Huixian HongFatima AlduraibiDavid PonderWayne L DuckCasey D MorrowJeremy B FooteTrenton R SchoebHuma FatimaCharles O ElsonHui-Chen Hsu John D Mountz

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

Our results suggest a model in which genetics play a dominant role in determining the initial development of autoimmunity. In contrast, gut microbiomes may regulate the persistence of certain aspects of systemic autoimmunity.

Keyphrases

magnetic resonance
multiple sclerosis
drug induced
computed tomography
contrast enhanced