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Analysing chemical composition and antimicrobial activity of geopropolis from Melipona scutellaris : HPLC-DAD and in vitro/in silico investigations.

Jéssica Lima de SouzaAdrianne Bastos FerreiraElinalva Maciel PauloClayton Queiroz AlvesCarlos Alfredo Lopes de CarvalhoFábio de Souza DiasAníbal de Freitas Santos JúniorHugo Neves BrandãoHumberto Fonseca de Freitas
Published in: Natural product research (2024)
This study evaluated the chemical profile, antimicrobial activity, and the presence of potentially toxic elements in geopropolis extracts produced by Melipona scutellaris in the Recôncavo region of Bahia, Brazil. It was found that the major chemical compounds belong to the class of phenolic compounds, with emphasis on the presence of gallic acid. In this study, no potentially toxic elements were found in the analysed geopropolis. Regarding the antimicrobial potential, gram-positive bacteria were susceptible to the action of geopropolis extract at concentrations of 0.25 to 2.5 mg.mL -1 , highlighting its microbiological activity against Streptococcus mitis (ATCC 00456) and Candida albicans (CCMB 251). Thus, this geopropolis extract can be used as a bacteriostatic rather than a bactericide. Our results suggest the potential for the economic and therapeutic use of M. scutellaris geopropolis, adding value to one of the meliponiculture products.
Keyphrases
  • candida albicans
  • ms ms
  • biofilm formation
  • oxidative stress
  • simultaneous determination
  • staphylococcus aureus
  • mass spectrometry
  • cystic fibrosis
  • molecular docking
  • anti inflammatory
  • human health