Assessing the linear and non-linear association of HbA1c with cardiovascular disease: a Mendelian randomisation study.

The study suggests a detrimental effect of HbA1c on coronary artery disease in both men and women, and the effect is via a glycaemic characteristic. The shape of the genetic association of HbA1c with these cardiovascular outcomes, in particular coronary artery disease, is likely to be linear.