Subunits of BK channels promote breast cancer development and modulate responses to endocrine treatment in preclinical models.

Corinna J MohrWerner SchrothThomas E MürdterDominic GrossSelina MaierBenjamin StegenAlice DragoiFriederike A SteudelSeverine StehlingReiner HoppeStephen MaddenPeter RuthStephan M HuberHiltrud BrauchRobert Lukowski

Published in: British journal of pharmacology (2020)

Breast cancer initiation, progression, and tamoxifen sensitivity depend on functional BK channels thereby providing a rationale for the future exploration of the oncogenic actions of BK channels in clinical outcomes with anti-oestrogen therapy.

Keyphrases

clinical trial
cell therapy
transcription factor
current status
breast cancer cells
mesenchymal stem cells
breast cancer risk
smoking cessation