Investigation of circulating metabolites associated with breast cancer risk by untargeted metabolomics: a case-control study nested within the French E3N cohort.

Elodie JobardLaure DossusLaura BagliettoMarco ForniliLucie LécuyerFrancesca Romana ManciniMarc J GunterOlivier TrédanMarie-Christine Boutron-RuaultBénédicte Elena-HerrmannGianluca SeveriJoseph A Rothwell

Published in: British journal of cancer (2021)

Perturbed metabolism compared to controls was observed in premenopausal but not postmenopausal cases. Histidine and NAC have known involvement in inflammatory pathways, and the robust association of ethanol with risk suggests the involvement of alcohol intake.

Keyphrases

breast cancer risk
mass spectrometry
ms ms
oxidative stress
liquid chromatography
postmenopausal women
weight gain
body mass index
physical activity
bone mineral density
body composition
case control
weight loss