Oligodendrocyte-specific ATF4 inactivation does not influence the development of EAE.

Yuan YueMilos StanojlovicYifeng LinGerard KarsentyWensheng Lin

Published in: Journal of neuroinflammation (2019)

These findings suggest the neuroprotective effects of PERK activation in oligodendrocytes in EAE, and rule out the involvement of ATF4 in oligodendrocytes in the development of EAE. These results imply that the protective effects of PERK activation in oligodendrocytes in MS and EAE are not mediated by ATF4.

Keyphrases

endoplasmic reticulum stress
transcription factor
multiple sclerosis
mass spectrometry
ms ms
endoplasmic reticulum
cerebral ischemia