Challenge N - versus O -six-membered annulation: FeCl 3 -catalyzed synthesis of heterocyclic N , O -aminals.
Giacomo MariLucia De CrescentiniGianfranco FaviFabio MantelliniDiego OlivieriStefania SanteusanioPublished in: Beilstein journal of organic chemistry (2024)
A new class of heterocyclic N , O -aminal and hemiaminal scaffolds was successfully obtained by means of a three-component reaction (3-CR) of 1,2-diaza-1,3-dienes (DDs), α-aminoacetals and iso(thio)cyanates. These stable imine surrogates are generated from key-substituted (thio)hydantoin intermediates through selective FeCl 3 -catalyzed intramolecular N -annulation.