Combination Blockade of the IL6R/STAT-3 Axis with TIGIT and Its Impact on the Functional Activity of NK Cells against Prostate Cancer Cells.

S González-OchoaMartha Cecilia Téllez-BañuelosA S Méndez-ClementeA Bravo-CuellarG Hernández FloresL A Palafox-MariscalJ HaramatiE J Pedraza-BrindisK Sánchez-ReyesPablo César Ortiz-Lazareno

Published in: Journal of immunology research (2022)

Our results reveal that the combined use of inhibitors directed against the IL6R/STAT-3 axis and TIGIT enhances the functional activity of NK cells against castration-resistant prostate cancer cells.

Keyphrases

nk cells
induced apoptosis
cell proliferation
cell cycle arrest
genome wide
single cell
gene expression
dna methylation