Translating pH-sensitive PROgressive saturation for QUantifying Exchange rates using Saturation Times (PRO-QUEST) MRI to a 3T clinical scanner.

We demonstrate that quantification of pH sensitive indices using PRO-QUEST is feasible at 3T within clinically acceptable acquisition times. Our initial findings in patients with MS show that pH sensitive indices varied with the type of lesion examined whereas no significant difference was found in healthy volunteers between tissue types, suggesting that it would be worthwhile to apply PRO-QUEST in a larger cohort of patients to better understand its distinct imaging features relative to conventional techniques.